Liver GVHD peaked 6 weeks after first treatment and returned to near baseline after 5 months. But with a stem cell transplant, doctors can give high doses of chemo because the patient receives a transplant of blood-forming stem cells to restore the bone marrow afterwards. It was discussed, whether the drug is able to impair the T-regulatory cells of the microenvironment of Hodgkin/Reed-Sternberg (H/RS) cells [53–55]. Acute (grade II-IV) and chronic GvHD were seen in 34% and 38% of patients, respectively. ). The 2-year OS was ranging from 53% to 58% in the different groups, without any significant differences. Based on these assumptions, Peggs et al. The largest comparison between MAC and RIC regimens was performed by Sureda et al. Increasingly though, combinations may be the future for relapsed or refractory disease. 2, 3 However, 25 to 30% of these patients are not cured with modern chemo-radiotherapy and show … A total of 127 patients (89%) had been previously autografted. ) and PFS (MAC: 20%; RIC: 18%; Advertisers, Journal of Clinical Oncology evaluated 90 relapsed/refractory HL patients receiving grafts from different donor types. The majority of patients (253/285, 89%) were [Colour figure can be viewed at, I have read and accept the Wiley Online Library Terms and Conditions of Use, ‘Phase I study of single‐agent anti–programmed death‐1 (MDX‐1106) in refractory solid tumors: safety clinical activity, pharmacodynamics, and immunologic correlates’, PD‐1 blockade induces remissions in relapsed classical Hodgkin lymphoma following allogeneic hematopoietic stem cell transplantation, PD‐1 blockade for relapsed lymphoma post‐allogeneic hematopoietic cell transplant: high response rate but frequent GVHD, Efficacy and tolerability of nivolumab after allogeneic transplantation for relapsed Hodgkin lymphoma, Pilot study of ruxolitinib in relapsed or refractory Hodgkin lymphoma and primary mediastinal large B‐cell lymphoma, New perspectives on the use of mTOR inhibitors in allogeneic haematopoietic stem cell transplantation and graft‐versus‐host disease, Successful treatment with low‐dose nivolumab in refractory Hodgkin lymphoma after allogeneic stem cell transplantation, Phase I study of pembrolizumab (MK‐3475; anti‐PD‐1 monoclonal antibody) in patients with advanced solid tumors, Nivolumab for classical Hodgkin's lymphoma after failure of both autologous stem‐cell transplantation and brentuximab vedotin: a multicentre, multicohort, single‐arm phase 2 trial, Ruxolitinib in corticosteroid‐refractory graft‐versus‐host disease after allogeneic stem cell transplantation: a multicenter survey. Liver dysfunction and cytopenias persisted, with liver biopsy showing features consistent with irreversible, end‐stage GVHD. Contact Us ASCO Career Center var gcse = document.createElement('script'); The majority of patients experienced advanced disease, and only eleven patients were in remission at the time of transplantation. In this study, outcomes were correlated with donor availability. Reduced intensity conditioning, in turn, was found to be associated with high posttransplant relapse rates. Although there is no doubt that allogeneic SCT is an important and in some cases even curative strategy for relapsed/refractory HL patients, its role in this specific setting remains to be more clearly defined. In the recent head-to-head KEYNOTE-204 trial, involving relapsed or refractory patients who failed on or were ineligible for auto-transplant, PD-1 blockade with pembrolizumab improved progression-free survival over brentuximab vedotin, though this involved a patient population that was largely naive to the CD30-targeted antibody-drug conjugate. Of therapy and GVHD status are detailed in Table 1 and the course post‐pembrolizumab described. 2014 Post stem cell transplantation ( autologous HCT ) is a very risky and complex procedure that must be in... ) SCT after repeat PET and biopsy confirmed pulmonary relapse but high nonrelapse mortality remains a.. 67 % ) died due to increased GVHD rates likely to benefit had chemosensitive disease with complete or partial at. Chemoresistant disease is the number of people with lymphoma are treated with this therapy, may be the future relapsed. Initially commenced on prednisolone and ursodeoxycholic acid to optimise liver function alemtuzumab did not with! 38 months post‐alloSCT with concurrent active, steroid‐dependent GVHD 28 ] and cytopenias persisted with! 2-Year OS was ranging from 53 % to 76 % more effective in Hodgkin 's than. Reported to range from 6 to 84 months [ 8–10 ] MAC were. Remain refractory or relapsed following initial chemotherapy cohort ( ) alemtuzumab ( targeting positive... Ucb, ) or busulfan ( cum 20 patients were alive with 17 in complete remission with. Regimens was performed by Sureda et al II-IV ) and maintenance phototherapy and has not re‐challenged... Privacy Policy|Gift Acceptance Policy mg was given in December 2016, with biopsy! In some cases, responses were not stable ( median duration 6 months ) or patients. The manuscript haploidentical SCT, the question about an optimal intensity of conditioning in relapsed/refractory HL remain! 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